Critical Dissection of Scientific Data

Course Directors: Carl Blobel, MD, PhD, Olga Boudker, Ph.D., and Christopher Mason, PhD
When: Quarters III and IV annually
Time: Thursdays, 1:30 pm – 3:00 pm
Start Date: Thursday, March 16, 2017
Where: 1300 York Avenue, C-200 Conference Room
Who: required for 1st PBSB students; 2nd year PBSB and Tri-I CBM students; Open to all WGSMS students

This course is required for all 1st and 2nd year PBSB graduate students, but is open to all WGSMS students. It is designed to train students in scientific presentation and critique. The structure is a formalized, in depth "journal club". Each 1st year student will choose a paper from a list provided by the Course Directors. Each 2nd year student will select a paper in their thesis field, subject to approval of the Course Directors. Each session will consist of a student formally presenting their selected paper to the class, which is expected to serve as a critical audience. The presentation should consist of an introduction of the relevant background literature, an objective presentation of the study, a subjective analysis/critique of the work, and suggestions for future work. Presentations by 2nd year students will be scheduled first, giving the 1st year students the opportunity to learn from their more senior colleagues. Grading will be based on presentation quality and contribution to constructive feedback.

Student GroupDateRoomFirst NameLast NamePaper Title
All16-MarC-200ChirsMasonCourse Introduction
30-MarC-200GabrieleCampanellaDermatologist-level classification of skin cancer with deep neural networks
30-MarC-200Shellie AnnDickMislocalisation of BEST1 in iPSC-derived retinal pigment epithelial cells from a family with autosomal dominant vitreoretinochoroidopathy (ADVIRC)
30-MarC-200ItaiDoronIgA-coated E. coli enriched in Crohn’s disease spondyloarthritis promote TH17-dependent inflammation
6-AprA-950Gabriel A.FitzgeraldMechanisms of amphetamine action illuminated through optical monitoring of dopamine synaptic vesicles in Drosophila brain
6-AprA-950Andre NeilForbesStem cell divisions, somatic mutations, cancer etiology, and cancer prevention
13-AprC-200Kevin M.Hadi
13-AprC-200In Sub MarkHan
20-AprC-200CamirRickettsLocal sequence assembly reveals a high-resolution profile of somatic structural variations in 97 cancer genomes
20-AprC-200R. LeaSanfordThe Effects of Acutely Administered 3,4-Methylenedioxymethamphetamine on Spontaneous Brain Function in Healthy Volunteers Measured with Arterial Spin Labeling and Blood Oxygen Level–Dependent Resting State Functional Connectivity
20-AprC-200ZijunZhaoSimultaneous Discovery, Estimation and Prediction Analysis of Complex Traits Using a Bayesian Mixture Model
27-AprC-200JamalElkhaderMeSHDD: Literature-based drug-drug similarity for drug repositioning
27-AprC-200AlexGorelickRelief of Profound Feedback Inhibition of Mitogenic Signaling by RAF Inhibitors Attenuates Their Activity in BRAFV600E Melanomas
27-AprC-200KonnorLaSuccinate dehydrogenase B-deficient cancer cells are highly sensitive to bromodomain and extra-terminal inhibitors
5-MayC-200MerveSahinLineage-Specific Genome Architecture Links Enhancers and Non-coding Disease Variants to Target Gene Promoters
5-MayC-200Jose NLoraNeonatal Transplantation Confers Maturation of PSC-Derived Cardiomyocytes Conducive to Modeling Cardiomyopathy
5-MayC-200XiaotongYaoStem cell divisions, somatic mutations, cancer etiology, and cancer prevention
11-MayC-200ShanaBergmanModeling the effects of the circadian clock on cardiac electrophysiology
11-MayC-200Dylan RichardMcNallyIdentification of methylation haplotype blocks aids in deconvolution of heterogeneous tissue samples and tumor tissue-of-origin mapping from plasma DNA
11-MayC-200Verdejo EvaForteaStructural Titration of Slo2.2, a Na+-Dependent K+ Channel
25-MayC-200Jordana KathrynThibado
25-MayC-200ChaoFengNetwork link prediction by global silencing of indirect correlations
2-JunC-200Ambrose GerardPlante
8-JunC-200Craig DiegoWestover

A-950 is at 1300 York Avenue